Founded during 218 A.S in partnership between Deep Space Engineering and Ageria Technologys it quickly became the leading financial company within the Sirius. Its planned purpose was for the constructions of jump gates and trade lanes outside of liberty.

Interspace Commerce expanded into Kusari and had set up Roppongi station in the New Tokyo system. Up until this point the Kusari goverment had banned all foreign immigration as well as the construction of foreign stations and businesses. It was a risky move and angered many Kusarian citizens, however Interspace Commerce stayed in Kusari. Groups of terrorism such as the Blood Dragons sprouted to stop foreign corruption into Kusari and became hostile to Interspace Commerce.

In 350 A.S, Interspace Commcerce became the primary financier of trade lanes for the other houses. In Rheinland, it constructed Bonn station in New Berlin to oversee its interests in 521 A.S. Later in 525 A.S Interspace Commerce agreed to forgive all debts to foreign houses, and turned control of the trade lanes and jump gates in those houses over to their governments. With this, Interspace Commerce collected tolls for using its jump gates and trade lanes for the next 200 years. The company has never been satisfied with the two hundred years of tolls it got in exchange, and it is for this chief reason that a good deal of animosity towards Rheinland and Kusari exists even today. As a result, Interspace Commerce often allows ships from the Bundschuh, Red Hessians and even the Unioners to dock and purchase supplies on Bonn station. In respone, the Rheinland military placed the Battleship Strausberg outside the station to keep an eye on Interspace's activities.

Interspace Commerce conducted the same dealings with the Golden Chrysanthemum terrorist movement and began to fund them as well. Rumors of this sprouted up but Interspace Commerce has called off these allegations as "slander".

In 700 A.S., Agiera and Interspace developed a project called the Universal Ship Identification system (USI) which gave Interspace Commerce the ability to track ships and lay tariffs appropriately. Some of the Houses expect this gives Interspace Commerce an edge in competition, however so far nothing has been proven. Piracy organisations such as the Lane Hackers broke into the system and kept track of shipments and raided them accordingly. It also gave shipping locations to other pirate groups like the Rogues and Outcasts.

When the Okinawa System was discovered at the Border Worlds in 812 A.S., both the GMG and Kishiro were eager to move in as fast as possible. In a deal with Interspace Commerce to invest and finance the development of the system, the GMG resentfully signed the deal with Interspace Commerce, who would get 5% of all H-fuel profits. Most piracy and raids in the system are suspected to have originated or sponsored by the Hogosha due to Interspace Commerce's dealings and influence with the Golden Chrysanthemum movement, which has prevented any Golden Chrysanthemum attacks in the system. Kishiro and the Gas Mining Guild ignored whenever a Golden Chrysanthemum vessel has been seen docking with Furyoku Station.

In 818 A.S., Interspace has grown tired of the Rheinland Government, and has begun doing actions as a means to draw attention to themselves. As instructed by the new CEO, they have begun as well strengthening their relations with the Red Hessians and Golden Chrysanthemums again. Being the only powerhouse cooperation in all of Sirius, many shady and what seems to be unnecessary transactions, become necessary to ensure complete control.