During the great wars of Sirius, deserted soldiers, refugees, and dislocated citizens of the Houses had to solve their problems somehow. Some of them, who had enough bravery and experience in offensive matters, tried to rob the supply lines, and during these actions they acquired a lot of prisoners and unarmed soldiers. They realized that those people were useful for the more dangerous jobs like war machine engineering and construction in space. However, since they were outlawed after their first actions and the Houses declared them as simple criminals, these groups had to find new partners to supply their actions. While the first messengers have arrived from the Edge and Border Worlds, the Hessians and the Outcast showed significant interest about gathering the slaves for a fair price. They saw the profit margins and realized that there could be a profitable trade here while gaining workers for their colonies in the distant edge worlds.

The Slavers Guild was originally comprised of several smaller groups delivering to different nations. As the operations grew stronger and more refined, the separated groups understood that they had to work together. After the infamous meeting on Barrier Gate station, these slaver groups established the Slavers Guild in 803 A.S. Following this, when the Outcasts and the Liberty Rogues pledged their alliance to one another 10 years later, the slaver convoys began to build up their main route between Planet Malta and Niverton Base. Since the Outcasts were experienced in the slave trade far before the Slavers Guild came to be, the Outcasts started to invest into bigger plantations and expanded their cardamine interests in Liberty and the Independent Systems.

While the slaver convoys passed across Cortez, they realized that the Orbital Spa and Cruise ships are viable targets to gain new meat for their business. Since the OSC convoys were less defensive than military convoys and roaming Freelancers, they were easy to pluck from the depths of space. As an added bonus, their knowledge of routes would enable the Slavers to better bypass certain systems, adding to the efficiency of their trade. The last main source of Slaves, were fugitive convoys who were trying to escape from the Bretonian warzones. They traveled across Magellan after the Gallic invasion, making them easy targets while flying from the Leeds Jumphole to Freeport 4. Since the Lane Hackers realized that the Slavers Guild could aid them with financial security and manpower from the Slaver trade, relations with the Slavers began to slowly improve.

As The Slavers Guild grew in strength, they began to look to other systems to expand their trade. A simple glance to Liberty and Rheinland showed the Slavers Guild that a ripe opportunity was presenting itself right before their eyes. The war between the two superpowers generated a endless supply of slaves from space battles. If a Slaver could get into the battle just before it began without being noticed, they could easily tractor in pilots who eject from their vessels. After that, it was simple. Just rush in, tractor the escape pods while both sides are distracted by their fight with each other, and jet out before either side knew what was happening. Less work for the Slavers and more profit in the long run. After this, the Slavers Guild opened relations with The Red Hessians and offered both Liberty and Rheinland officers alike to them as slaves for use in their mining operations in deep space. The Blood Diamond trade more than offset their price of the slaves and the Hessians enjoyed their former enemies working for them in the harsh conditions of space.

As time passed, The Slavers Guild grew in power, influence, and gained ample resources. With this, they began to build their own fleet, they began hiring mercenaries for recon missions, and assassins to assassinate their enemies who would dare to encroach on their routes. Since many departments of the Liberty Police were corrupt, many began to allow prisoners to "escape" right into the Slavers hands just outside of Sugarland.

With The Guild's power increasing, the rich Freelancer of The Barrier Gate in Coronado took notice. He began talks with The Slavers Guild with the hopes of increased trade to his station. The location of Barrier Gate in the middle of the trade routes the Guild so often used, it was a no-brainer to have their main place of operations seated right in the middle. Also, since the high demand of Human Organs at the station were predominant, the guild often supplied Barrier Gate with a healthy supply for injured soldiers. These soldiers were recovering from serious injuries and more often than not, became healthy allies of the Guild after their recovery. However, the Human Organ trade created diplomatic problems for the Guild: It created misunderstandings between the Corsairs and the Slavers Guild. Since they established their very first agreement with the Outcasts and because the Outcasts weren't the best of friends with the Corsairs, this created friction and tension between the Slavers Guild and the renegade pirates. However, business is business.

Nowadays, the Slavers Guild is planning to expand their fleet with some capable fighters and freighter class support ships. They would like to expand their interests in Gallia and have sent some "sentinels" to the borders of the distant Gallic systems. However, the situation is complicated there and the only one way to enter Gallia without attention, is acting like Junkers and misleading the lawful groups there. Also, the Slavers Guild has been known recently to smuggle things other than Slaves. Things such as Cardamine, Synthetic Marijuana, and other contraband has been sighted in recent months. Many times simply because this is through contract, but the true reason is up for speculation.