While using the older DXVK libraries provided by the guide did work, I came across a reproducible crash involving a ship model (Akhetaten).
My fix was to remove the DXVK libraries from the game directory and instead use the newest ones provided by the package manager.
To install the package manager libraries on the Discovery wine prefix, you must set it as default with an environment variable:
export WINEPREFIX=/dir/to/disco/prefix
And then run setup_dxvk install, the script should come bundled with the package, and it's intended to install DXVK on wine prefixes, this script also ensures to setup environment variables so that Lutris properly detects DXVK.