If you want to test it, Connecticut is your system. The JH to NY is in the middle (find exact spot with /pos if you wish)
Edit:
Quote:I suspect folks sitting on Toledo would be able to hear each other, as well as anyone on the Isis, but the folks on the Isis would not be able to hear themselves or the folks on Toledo...
No, I don't think that's correct... All players docked on a base in a system have position 0,0,0 - for transmitting AND for receiving local communication (they just have the position, so it gets used for everything). The position of the actual base is irrelevant, the game doesn't care about it. As a result, all ships docked on any base in the same system should hear each other in local.
Btw, this is just my theory, I didn't actually test it.