Warhammer Fantasy Roleplaying 2e here. The game's a ton of fun, uses the D100 system rather than D&D's D20. Also employs a career type advancement scheme, where you enlist in a career then complete it and move to another one. Allows for either specialist or generalist characters. I've never played D&D, so I won't try to make any direct comparisons mechanics or setting wise.
Inquisitor (set in Warhammer 40k) is at it's heart a tabletop game with RP elements. No real levelling or XP system built-in instead opting for the rather more realist build a character ahead of time who is already skilled. The best things about this game are the absolute freedom to do anything the GM is willing to go with (total freedom to create your own character ideas, while GM should help balance and so on). The detail of the game is also magnificent, which can be both an attribute and a frustration.