First of all, I am a excessive weapon group user. It is essential for dogfights, to have instant access to the various groups (shield busters/hull breakers/SNAC).
But I discovered a very annoying thing: After I dock and undock, my weapon groups are sometimes scrambled or mixed. So I might have the weapon group one doubled and no weapon group on button two.
That is really strange and killed me more then one time, yet. Imagine you are in a battle and recognize, that you can't switch quickly.
Drives me crazy when I have to leap into my fighter to scramble to a fight, get ready to shoot my Inferno to get their shields down and.. say what? Hellfuries shoot? Dang.
If you find yourself in combat with messed up weapon groups, holding shift and pressing numbers 1-9 allows you to quickly select and deselect weapons. After a few trys you'll be able to quickly fix your weapon groups in just a couple seconds in the middle of a fight.